团队成果发表:催产素调控静息状态下注意相关的大尺度脑网络——Cerebral Cortex
Source: | Author:辛斐 | Publish time: 2018-10-29 | 374 Views | Share:

 鼻喷催产素调控静息状态下注意相关的大尺度脑网络

NeuSCAN实验室辛斐博士于2018年11月在认知神经领域国际顶级期刊Cerebral Cortex 发表了题为“Oxytocin modulates the intrinsic dynamics between attention-related large-scale networks”的论文,Benjamin Becker教授为通讯作者。该研究利用功能磁共振技术,首次系统探讨了鼻喷催产素对人类被试静息态下大尺度脑网络间功能连接的调节效应。通过比较94名催产素组被试和93名安慰剂控制组被试静息态下大尺度脑网络间的功能交互,发现催产素增强了负责内部注意指向的默认网络和负责外部注意指向的背侧注意网络及突显网络之间的功能反相关,同时增强了默认网络和突显网络内部子网络间的功能正相关。本研究没有发现催产素对脑网络功能连接调节的性别差异,但发现催产素对默认网络-突显网络间功能连接的影响受到受试者自闭特质的影响。这些发现表明催产素可以通过调节负责内部注意指向的默认网络和负责外部注意指向的背侧注意/突显网络之间的功能交互来促进有效的注意分配。 
Oxytocin modulates the intrinsic dynamics between attention-related large-scale networks 
Authors

Fei Xin1, Feng Zhou1, Xinqi Zhou1, Xiaole Ma1, Yayuan Geng1, Weihua Zhao1, Shuxia Yao1, Debo Dong1, Bharat B. Biswal1,2, Keith M. Kendrick1, Benjamin Becker1*

Published in Cerebral Cortex (2018)

 

Attention and salience processing have been linked to the intrinsic between- and within-network dynamics of large-scale networks engaged in internal (default network, DN) and external attention allocation (dorsal attention network, DAN; salience network, SN). The central oxytocin (OXT) system appears ideally organized to modulate widely distributed neural systems and to regulate the switch between internal attention and salient stimuli in the environment.

The current randomized placebo (PLC) controlled between-subject pharmacological resting-state fMRI study in N = 187 (OXT, n = 94; PLC, n = 93; single-dose intranasal administration) healthy male and female participants employed an independent component analysis (ICA) approach to determine the modulatory effects of OXT on the within- and between-network dynamics of the DAN-SN-DN triple network system. OXT increased the functional integration between subsystems within SN and DN and increased functional segregation of the DN with both attentional control networks (SN and DAN). Whereas no sex differences were observed, OXT effects on the DN-SN interaction were modulated by autistic traits.

Together, the findings suggest that OXT may facilitate efficient attention allocation by modulating the intrinsic functional dynamics between DN components and large-scale networks involved in external attentional demands (SN, DAN).