讲座通知-Daniel Quintana
Source: | Author:李琴 | Publish time: 2018-11-16 | 366 Views | Share:
时    间:2018年11月20日星期二上午10:00-11:00
地    点:电子科技大学清水河校区综合楼131办公室
主讲人:Daniel Quintana博士
主持人:Benjamin Becker教授

主讲人介绍:
Daniel Quintana博士,澳大利亚人,于2007年获得麦考瑞大学(Macquarie University)心理学本科学位,2013年获得悉尼大学心理学博士学位。 目前在挪威精神疾病研究中心从事博士后工作,主要研究领域为催产素的社会情绪调节及对神经环路的影响。在Molecular Psychiatry, JAMA Psychiatry, Biological Psychiatry, American Journal of Psychiatry等国际一流期刊上发表论文60多篇,获得多项科学研究经费。H指数26, 引用次数约3000次(谷歌学术)。
相关链接:
http://www.dsquintana.com
https://scholar.google.com/citations?user=3BsdBosAAAAJ&hl=zh-CN



报告题目: Oxytocin’s modulatory effects on social cognition: The role of intranasal dose and delivery

报告摘要:
The neuropeptide oxytocin has garnered considerable interest for its role in social behavior and its potential for the treatment of psychiatric illnesses characterized by social dysfunction. However, research needs to first demonstrate engagement of intranasal oxytocin targets and to define the optimal dose before it can be translated to the clinic. I will describe a study identifying whole brain voxel-by-voxel gene expression patterns of the oxytocin receptor (OXTR) gene and its association with cognitive states via a large-scale fMRI meta-analysis of 14,371 studies. OXTR gene expression was increased in subcortical and olfactory regions and expression patterns were associated with anticipatory, appetitive, aversive, and social cognitive states. Data from two clinical trials will also be presented demonstrating that compared to placebo, 8 international units (IU) of intranasal oxytocin (but not 24IU intranasal oxytocin or 1IU intravenous oxytocin) modulates social cognition, pupil diameter, and neural activity. Altogether, these studies provide the first steps towards identifying targets for oxytocin receptor engagement in the human brain and suggest that a lower 8IU intranasal dose might be more efficacious than the conventional 24IU dose.